FULL PROGRAM...
detailed Full Program sessions chapter 2...
Part 2.2: Novel Vaccine Discovery Technology
Section 2-2-1: Bioinformatics, Antigen Design, and Vaccine Development
Time: March 23, 2011 13:30-17:10
Part 2.2: Novel Vaccine Discovery Technology
| Section 2-2-1: Bioinformatics, Antigen Design, and Vaccine Development Time: March 23, 2011 13:30-17:10 | |
Chair:  | Dr. Vidadi M. Yusibov, Executive Director, Fraunhofer USA Center for Molecular Biotechnology, USA |
Co-Chair:  | Dr. Yongqun ”Oliver” He, Assistant Professor, University of Michigan Medical School, USA |
| 13:30-13:55 | Title: Using Comparative Bacterial Genomics to Identify Novel Vaccine Targets Dr. Garth D. Ehrlich, Director, Department at Allegheny Singer Research Institute, Center for Genomic Sciences, USA |
| 13:55-14:20 | Title: VLP-based Vaccine against Malaria Dr. Vidadi M. Yusibov, Executive Director, Fraunhofer USA Center for Molecular Biotechnology, USA |
| 14:20-14:45 | Title: Computational Antibody Vaccine Discovery by Conformational Epitope Prediction and Design of Novel Protein Scaffolds Dr. Vaikuntanath Samudrala, Associate Professor, Computational Biology Group, University of Washington, USA |
| 14:45-15:10 | Title: Systematic Analysis of Vaccine Targets of Bacterial Pathogens Using Vaxign Reverse Vaccinology Dr. Yongqun ”Oliver” He, Assistant Professor, University of Michigan Medical School, USA |
| 15:10-15:30 | Coffee Break |
| 15:30-15:55 | Title: Decoding Non-coding Dna Codes: Human Genome Meta-chromosomes Architecture Dr. Jean-Claude Perez, Individual Researcher, Bordeaux, France (support from Pr Luc Montagnier FMPRS World AIDS Foundation UNESCO and Jean-rené Fourtou Vivendi Universal chairman) |
BIT Life Sciences’ 3rd World Congress of Vaccine Beijing·China
Session Name: Section 2-2-1: Bioinformatics, Antigen Design, and Vaccine Development
Decoding non-coding Dna Codes: Human Genome Meta-Chromosomes Architecture
Dr. Jean-Claude Perez* support from Pr Luc Montagnier World AIDS Foundation UNESCO
and Jean-René Fourtou Vivendi Universal chairman
Abstract
The question of the hypothetical function of the 98% non-coding DNA of the human genome remains one of the major open problems of Genetics. In 2010, we prooved that the entire human genome codon population is fine-tuned around the "Golden ratio" ("Codon Populations in single-stranded DNA Whole Human Genome Are fractal and fine-tuned by the Golden Ratio 1618" , 2010, Interdisciplinary Science). We show how, across the entire human genome, there appears to be an overall balance in the whole single-stranded DNA. This digital balance fits neatly around 2 attractors whose predominant values are 1 and (3-Phi)/2, where Phi is the Golden Ratio. Yet, the same analysis applied to each of our 24 chromosomes and to each of the 25 chromosomes of the chimpanzee (book “Codex Biogenesis”, 2009), will reveal a strange phenomenon: while this study shows that populations of the respective genome codons of humans and chimpanzees are 99.99% correlated. It appears, also, that some human chromosomes are more similar to chimpanzee chromosomes than other human chromosomes. And vice versa. We then identified two clusters of chromosomes in humans and two other clusters in the chimpanzee chromosomes that correlated. Some human chromosomes (16 17 19 20 and 22) will appear at the extremity. Simultaneously, a study of the affinities of integrating HIV type genomes within various human chromosomes (Mitchell et al, 2004) have demonstrated a permeability 2 to 3 times that of all other chromosomes for chromosomes 16 17 19 and 22 which appear exactly in this extremity cluster. Thus, we are confronted with a paradox: the same analysis shows a global unity across the genome, whereas, applied to each of the constituent chromosomes of this same genome a great heterogeneity between these chromosomes is revealed. The objective of this study is, precisely, to analyse this paradox in greater depth. Then, we discovered a meta-structure that overlaps all 24 human chromosomes. It is based on a set of strong numerical constraints based particularly on Pi, Phi and integers numbers such as 2, 3 etc. A functionality of this fine-tuned structure appears: the structure is 90% correlated with the density of genes per chromosome from the Human Genome project. It is 89% correlated with the chromosome's permeability to intrusion by retroviruses like HIV, 94% with CpG density and 62% with SNP inserts/deletes. Finally, we discovered a classification network of the 24 human chromosomes, including one measuring scale, ranging from 1/Phi (chromosome 4) to 1/Phi + 1/Pi (chromosome 19), which is both correlated with the increasing density of genes and permeability to the insertion of external viruses or vaccines. To close this speech, we speculate on a powerful basic Pi, Phi based numerical projection law of the C O N H S P bio-atoms average atomic weights. We will reveal an integer number based code which unifies the 3 worlds of genetic information: DNA, RNA and amino acids. Correlating, synchonizing and matching Genomics/Proteomics global patterned images in all coding/noncoding DNA sequences, all biologic data is unified from bioatoms to genes, proteins and genomes. This code applied to the whole sequence of human genome, produces generalized discrete waveforms. We will show that, in the case of the whole double-stranded human genome DNA, the mappings of these waves fully correlate with the well known Karyotype alternate dark/grey/light bands.
Biography
Jean-Claude Perez, Ph.D. (Bordeaux university), is a French interdisciplinary scientist born in 1947 in Bordeaux (France). Perez worked with IBM in both Biomathematics and Artificial Intelligence research, inventing the "Fractal Chaos" neural network, his holographic-like memory « deja vu » novelty detector. In 1990, Perez published research showing strong links between both the worlds of fractals and Fibonacci numbers, which are based on the Golden ratio. In this last area, with "dna supracode", he proved that the DNA coding for genes is structured by proportions related to Fibonacci numbers. He verified this discovery in the field of the HIV genome, in partnership with Nobel Prize-winner Luc Montagnier. Perez has worked for 20 years in the fields of whole-genome numerical analysis and the numerical decoding of genes as coding or non-coding DNA sequences. Perez has also published five books, notably: L'ADN décrypté – 1997 and Codex Biogénésis, (Resurgence, Belgium – 2009.), registered an international Patent for high temperature superconductors (1994) and produced an audio CD entitled “The first music of genes” (1994). Awards: 1991 "Denis Guichard" prizewinner from the "Fondation de France".
* Dr. Jean-Claude Perez, Independent researcher, Bordeaux, France jeanclaudeperez2@free.fr http://golden-ratio-in-dna.blogspot.com/
