October 2013: the first proof that complete human genome codon triplets population DNA single strand is a WHOLE: the 3 genomic numbers discovery article

October 2013 APPLIED MATHEMATICS 
(special issue BIOMATHEMATICS)

The “3 Genomic Numbers” discovery:

How our genome single-stranded DNA sequence

 is “self-designed” as a numerical whole

Jean-claude Perez

Email: jeanclaudeperez2@gmail.com

Received May 22, 2013; revised June 10, 2013; accepted June 14, 2013

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Note:

All results presented in this article are REPRODUCIBLE by other researchers from the following basic information:

[3] International Human Genome Project Sequencing Centers

and Verified by NCBI and UCSC, “Human Genome Finalized

BUILD34. Build 34 Finished Human Genome

Assembly,” 2003.

http://genome.ucsc.edu/FAQ/FAQreleases.html

and

Table 3 of the article pp 40.

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The article is now available in OPEN ACCESS on line:

details access:

access:

http://www.scirp.org/journal/PaperInformation.aspx?PaperID=37457

from SCIRP scientific research APPLIED MATHEMAICS website http://www.scirp.org/journal/AM/

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The “3 Genomic Numbers” discovery:

How our genome single-stranded DNA sequence

 is “self-designed” as a numerical whole

Copyright © 2013 Jean-claude Perez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

"The beginning (1) is the middle (2) of the whole (Phi)"  

Here is my interpretation of this famous sentence from Pythagoras[2]...

Abstract

This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons comprising the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it's as if the memory of a fossil genome with multiple symmetries persists. This recalls the "intermingling" of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, that characterize it and its 64 codon populations with correlations greater than 99%. The number "1" is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then "imagine" a kind of hyperspace formed by these codon populations. Then we revisit  the value (3-Phi) / 2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome : we will show that - simultaneously with the duality between genes and junk DNA - there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information / redundancy involving golden ratio proportions.

Keywords : genetic code; codon populations; junk DNA; cancer genomics chromosomal translocations; genomes diversity; chromosomes diversity; whole human genome DNA sequence; “Phi” the golden ratio; Fibonacci numbers;  information theory;  symmetry; cellular automata; Chargaff’s  codon  level symmetry principle; fractal self-similarity; “e” Euler's number; “Pi”; form and substance; redundancy; encryption.

[1]
      This article publishing was supported by Professor Luc Montagnier, Fondation Mondiale Recherche et Prévention SIDA

                UNESCO 1, rue Miollis 75732 Paris Cedex 15 Web site: http://montagnier.org/index.php

[2]    “1”, ”2” and “Phi the golden ratio” are the 3 genomic numbers characterizing codon populations of the whole human genome.

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FULL TEXT other link (PDF):
http://fr.scribd.com/doc/169323556/7401586of18september2013

published 4 october 2013 in open access by http://www.scirp.org/journal/am/

10B access